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The synthesis of BODIPY dyes have increase in the last years owe to wide application of this compounds. However, the typical fluorescense of BODIPYs start from the green to the NIR. The publication of BODIPYs with blue fluorescense was a new development.

Blue Dyes (Undergraduate research)

I have a broad interest in synthesis of organic compounds, principally in fluorescent compounds and its application in material science, medicine and biology.

  • C. F. Azael Gómez-Durán, Inmaculada García-Moreno, Ángel Costela, Virginia Martín, Roberto Sastre, Jorge Bañuelos, Fernando López Arbeloa, Iñigo López Arbeloa, and Eduardo Peña-Cabrera, “8-PropargylaminoBODIPY: Unprecedented Blue-emitting Pyrromethene Dye. Synthesis, Photophysics and Laser Properties”. Chem. Comm. 2010, 5103.

 

  • Jorge Bañuelos, Virginia Martín, C. F. Azael Gómez-Durán, Ismael J. Arroyo Córdoba, Eduardo Peña-Cabrera, Inmaculada García-Moreno, Ángel Costela, M. Eugenia Pérez-Ojeda, Teresa Arbeloa, and Iñigo López Arbeloa “New 8-Amino-BODIPY Derivatives: Surpassing Laser Dyes at Blue-Edge Wavelengths”, Chem. Eur. J. 2011, 7261.

 

  • Carlos Osorio-Martinez, Arlette Urias Benavides, C. F. Azael Gómez-Durán, Jorge Bañuelos, Ixone Esnal, Iñigo Lopez Arbeloa, and Eduardo Peña Cabrera “8-AminoBODIPYs: Cyanines or Hemicyanines? The Effect of the Coplanarity of the Amino Group on their Optical Properties”J. Org. Chem. 2012, 5434.

BODIPY dyes posses great photophysical properties that allows its aplication in different areas such as development of new materials, bioimaging and laser manufacturing. In other hand, TPE (Tetraphenylethene) is a molecules that posses AIE (Aggregation Induced Emission) effect and have been widely use in healty area for cell imaging and development of new materials, the synthesis of hybrids BODIPY-TPE produce new molecules with interesting properties.

BODIPY-TPE (Ph.D. Research)

  • Rongrong Hu, C. F. Azael Gómez-Durán, Jacky W. Y. Lam, José L. Belmonte-Vázquez, Chunmei Deng, Sijie Chen, Ruquan Ye, Eduardo Peña-Cabrera, Yongchun Zhong, Kam Sing Wong, and Ben Zhong Tang “Synthesis, solvatochromism, aggregation-induced emission and cell imaging of tetraphenylethene-containing BODIPY derivatives with large Stokes shifts” Chem. Comm. 2012, 10099.

 

  • Cesar F. Azael Gomez-Duran, Rongrong Hu, Guangxue Feng, Tingzhong Li, Fan Bu, Mathieu Arseneault, Bin Liu, Eduardo Peña-Cabrera, Ben Zhong Tang. “Effect of AIE substituents on the fluorescence of tetraphenylethene-containing BODIPY derivatives” ACS Appl. Mater. Interfaces 2015, 15168

Orthogonal Reactivity BODIPY(Ph.D. Research)

The development of new methods to synthesize BODIPYs is important to synthesize different families of these dyes. Functionality of BODIPYs have been widely study, however, a strategy that allow functionalize with different reactions is not completely known. This novel synthetic protocol is a powerful route to generate a library of compounds with desired photophysical properties.

Squaraine Dyes Synthesis(Postdoctoral Research)

  • Cesar F. A. Gómez‐Durán, Ixone Esnal, Ismael Valois‐Escamilla, Arlette Urías‐Benavides, Jorge Bañuelos, Iñigo López Arbeloa, Inmaculada García‐Moreno, Eduardo Peña‐Cabrera. “Near‐IR BODIPY Dyes à la Carte—Programmed Orthogonal Functionalization of Rationally Designed Building Blocks” Chem. Eur. J. 2016, 1048.

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  • Nerea Epelde-Elezcano, Virginia Martínez-Martínez, Eduardo Peña-Cabrera, Cesar F. A. Gómez‐Durán, Iñigo López Arbeloa, Sylvie Lacombe. “Modulation of singlet oxygen generation in halogenated BODIPY dyes by substitution at their meso position: towards a solvent-independent standard in the vis region” RSC. Adv. 2016, 41991.

Squaraine dyes posses near infrared emission and this propertie has been used widely for different applications such as cellular imaging, sense ions and recently flu detection technology. Threading of tetralactam macrocycle with squaraine dye provide two technologies preassembly and in situ capture. The difference of these technologies is preassembly based on long stability of complex  (slow threading/dethreading) and in situ capture based on fast threading and quick fluorescense response (applied for flu detection).

  • Wenqi Liu, César F. A. Gómez-Durán, Bradley D. Smith. “Fluorescent Neuraminidase Assay Based on Supramolecular Dye Capture After Enzymatic Cleavage” J. Am. Chem. Soc. 2017, 6390.

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